Blood coagulation is the result of a series of clotting factor enzyme chain reaction. Blood clotting factor in an inactive zymogen form, when certain coagulation factors are activated, allows many clotting factors according to a certain order has been activated, there are complex catalysis between each other, known as the theory. changeable the theory generated on the biophysical characteristics of the blood showed an increase in resistance (current law) enhanced viscosity (beads), the turbidity increases (optical method). Since the current measurement reliability is poor, so the beads method and replaced by optical method.

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